Curriculum vitae
Peter Frank Whitington, M.D.
November
2004
Office Address:
Children’s Memorial Medical Center
2300 Children’s Plaza, #57
Chicago, IL 60614-3994
Phone:
(773) 880-4643
Fax:
(773) 975-8671
E-mail:
p-whitington@northwestern.edu
Education and Training
1968 BA (Economics), Tulane University, New Orleans, LA
1971 MD, University of Tennessee Center for the Health Sciences, Memphis, TN
1972 - 1974 Resident in Pediatrics, University of Tennessee Center for the Health Sciences
1974 Chief Resident in Pediatrics, University of Tennessee Center for the Health Sciences
1975 - 1977 Research Fellow, Gastroenterology, The Johns Hopkins Hospital, Baltimore, MD
1977 Recipient of National Institute of Health postdoctoral research fellowship, #HD 05533-01
1977 - 1978 Research Fellow, Gastroenterology, Department of Pediatrics, University of Wisconsin, Madison, WI
Current Professional Appoinments
Professor, Northwestern University, Feinberg School of Medicine, Departments of Pediatrics and Medicine
The Sally Burnett Searle Professor of Pediatrics and Transplantation, Northwestern University, Feinberg School of Medicine
Division Head of Gastroenterology, Hepatology and Nutrition, Children’s Memorial Medical Center
Director of Organ Transplantation and the Siragusa Transplantation Center, Children’s Memorial Medical Center
Active Board Certification and Medical Licensure
American Board of Pediatrics, Gastroenterology Sub-Board #267
American Board of Pediatrics #20292
Illinois Medical License #0336-032725
Active Society Memberships
International Society for Pediatric Transplantation
American Society of Transplantation
American Association for the Study of Liver Diseases
American Gastroenterological Association
Society for Pediatric Research
North American Society for Pediatric Gastroenterology and Nutrition
Current Community Service/Advocay
Member, Board of Directors, Illinois Chapter, American Liver Foundation
Member, Scientific Advisory Board, Alagille Syndrome Alliance, Tigard, Oregon
Medical Director, Johnny Genna Foundation, Chicago
Elected, Federal and Other Consultant Appointments (1999-2004)
2004 Member NIH Hepatobiliary pathophysiology (HBPP) study section, October 4-5, 2004
2003 Member, NIH – NIDDK Special Emphasis Panel, ZDK1 GRB-9 O4, Small Clinical Grants in Digestive Diseases and Nutrition, July 17, 2003.
2002 - 2005 Executive Council, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
2000 - 2003 Member, American Society of Transplantation, Public Policy Committee
1999 – 2002 Member, American Society of Transplantation, Practice Guidelines Committee
1998 - 2001 Member, American Society of Transplantation, Pediatric Committee
1996 - 1999 Member, Executive Committee of SPLIT (Studies of Pediatric Liver Transplantation)
Current Editorial Service
Editorial Board, Hepatology
Editorial Board, Liver Transplantation
Editorial Board, Pediatric Transplantation
Reviewer for: Gastroenterology
Hepatology
New England Journal of Medicine
Journal of Pediatric Gastroenterology and Nutrition
Pediatric Research
American Journal of Physiology
Journal of Pediatrics
Digestive Diseases and Sciences
Pediatrics
Transplantation
Liver Transplantation
Pediatric Transplantation
American Journal of Transplantation
Current Grant Funding
NIH-NIDDK 1U01 DK62436
Biliary Atresia Clinical Research Consortium
PI: Peter F. Whitington
Award Period: 9/02 – 5/07
Award Amount: $850,000
Major Invited Lectures, Symposia and Visiting Professorships (2002-04)
Invited speaker: AASLD/NASPGHN Pediatric Symposium “Acute Liver Fialure”, Boston, October 29, 2004. Lecture entitled: “Fetal and Neonatal Liver Fialure Secondary to Iron Storage Dsisease”.
Invited speaker: Update in Pediatric Liver Disease/Liver Transplantation, Mount Sinai School of Medicine, New York, October 19, 2004. Lecture entitled: Neonatal Liver Failure: Diagnoses and Treatment.
Invited speaker: International Symposium on Living Donor Transplantation, Essen Germany, September 2-3, 2004. Lecture entitled: “Living donor liver transplantation in children: US experience”.
Invited speaker: DDW 2004 (AASLD/NASPGHN joint liver symposium), New Orleans, May 16, 2004. Lecture entitled: “Liver failure in the neonate”.
Invited speaker: National Congress of Pediatric Gastroenterology, Hepatology and Nutrition, Ankara Turkey, May 5-7, 2004. Lectures entitled: “Living donor liver transplantation” and “The molecular and physiologic basis of genetic cholestasis”.
Invited speaker: Issues in Neonatology 2004, Garden City, Long Island, NY, March 18, 2004. Lecture entitled: “Neonatal Liver Failure”.
Visiting Professor, University of Tennessee Center for the Health Sciences, Department of Pediatrics, Memphis TN, October 21 - 22, 2003. Pediatric Grand Rounds entitled: “The evolution of living donor liver transplantation in children and its current status”, research conference entitled “Osteopontin and the liver”.
Grand Rounds, University of Illinois Medical School, Department of Surgery, June 5, 2003. Lecture entitled: “The evolution of living donor liver transplantation in children and its current status”.
Invited speaker: Second Argentine Congress of Pediatric Gastroenterology and Hepatology, Buenos Aires, September 30 – October 1, 2002. Lectures entitled: “A paradigm: Portal Hypertension in Children”, “Neonatal Cholestasis: Ongoing Challenge” and “Neonatal Hemochromatosis”.
Original Articles
1. Whitington PF, Gibson R. Soy protein intolerance: four patients with concomitant cow's milk intolerance. Pediatrics 1977;59:730-2.
2. Whitington PF, Barnes HV, Bayless TM. Medical management of Crohn's disease in adolescence. Gastroenterology 1977;72:1338-44.
3. Whitington PF, Shermeta DW, Seto DSY, Jones L, Hendrix TR. Role of lower esophageal sphincter incompetence in recurrent pneumonia after repair of esophageal atresia. J Pediatr 1977;91:550-4.
4. Shermeta DW, Whitington PF, Seto DS, Haller JA. Lower esophageal sphincter dysfunction in esophageal atresia: nocturnal regurgitation and aspiration pneumonia. J Pediatr Surg 1977;12:871-6.
5. Whitington PF, Friedman AL, Chesney RW. Gastrointestinal disease in the hemolytic-uremic syndrome. Gastroenterology 1979;76:728-33.
6. Whitington PF, Black DD. Cholelithiasis in premature infants treated with parenteral nutrition and furosemide. J Pediatr 1980;97:647-9.
7. Cukier JO, Whitington PF, Odell GB. The bilirubin UDP-glucuronyl transferase of liver in postmature rats: a functional and morphologic comparison. Lab Invest 1981;44:368-74.
8. Whitington PF, Olsen WA, Odell GB. The effect of bilirubin on the function of hamster small intestine. Pediatr Res 1981;15:1009-14.
9. Whitington PF. Effect of jaundice phototherapy on intestinal mucosal bilirubin concentration and lactase activity in the congenitally jaundiced (Gunn) rat. Pediatr Res 1981;15:345-8.
10. Black DD, Suttle EA, Whitington PF, Whitington GL, Korones SD. The effect of short-term total parenteral nutrition on hepatic function in the human neonate: a prospective randomized study demonstrating alteration of hepatic canalicular function. J Pediatr 1981;99:445-9.
11. Burckart GJ, Whitington PF. The effect of prostaglandin E1 on the reserve bilirubin-binding capacity of albumin. J Pediatr 1981;99:1003.
12. Burckart GJ, Whitington PF, Helms RA. The effect of two intravenous fat emulsions on bilirubin binding to albumin. Amer J Clin Nutr 1982;36:521-6.
13. Burckart GJ, Whitington PF, Gross SR. Reserve bilirubin binding capacity determined by difference spectroscopy. I. Modifications and performance of the difference spectroscopy assay. J Pediatr Gastro Nutr 1982;1:489-94.
14. Whitington PF, Burckart GJ, Gross SR, Korones SB, Helms RA. Alterations in reserve bilirubin binding capacity of albumin by free fatty acids. II. In vitro and in vivo studies using difference spectroscopy. J Pediatr Gastro Nutr 1982;1:495-501.
15. Lake AM, Whitington PF, Hamilton SR. Dietary protein-induced colitis in breast-fed infants. J Pediatr 1982;101:906-10.
16. Schwarzenberg SJ, Whitington PF. Colonic stricture complicating formula protein intolerance enterocolitis. J Pediatr Gastro Nutr 1983;2:190-2.
17. Orenstein SR, Whitington PF. Choledochal cyst resulting in congenital cirrhosis. Amer J Dis Child 1983;136:1025-6.
18. Schwarzenberg SJ, Whitington PF. Rectal gastric mucosal heterotopia as a cause of hematochezia in an infant. Dig Dis Sci 1983;28:470-2.
19. Burckart GJ, Whitington PF, Halbrehder DK, Helms RA. Triglyceride and fatty acid clearance in neonates following safflower oil emulsion infusion. J Parent Ent Nutr 1983;7:251-3.
20. Whitington PF, Stapleton FB. Ontogeny of hepatic peroxisomal uricase activity in the mongrel puppy. Pediatr Res 1983;17:714-6.
21. Odell GB, Gutcher GR, Whitington PF, Yang G. Enteral administration of agar as an effective adjunct to phototherapy of neonatal hyperbilirubinemia. Pediatr Res 1983;17:810-4.
22. Orenstein SR, Orenstein DM, Whitington PF. Gastroesophageal reflux causing stridor. Chest 1983;84:301-2.
23. Orenstein SR, Whitington PF. Positioning for prevention of infant gastroesophageal reflux. J Pediatr 1983;103:534-7.
24. Orenstein SR, Whitington PF, Orenstein DM. The infant seat is detrimental in gastroesophageal reflux. N Engl J Med 1983;309:760-3.
25. Li BU, Whitington PF, Odell GB. The reversal of bilirubin-induced intestinal secretion by agar. Pediatr Res 1984;18:79-82.
26. Orenstein SR, Magill HL, Whitington PF. Ileal dysgenesis presenting with anemia and growth failure. Pediatr Radiol 1984;14:59-61.
27. Cooke RJ, Whitington PF, Kelts D. Effect of taurine supplementation on hepatic function during short-term parenteral nutrition in the premature infant. J Pediatr Gastro Nutr 1984;3:234-8.
28. Orenstein SR, Whitington PF. Intestinal bacterial overgrowth in the pediatric patient. J Tenn Med Ass 1984;77:198-201.
29. Whitington PF, Orenstein SR. Manometric guidance of esophageal biopsy. J Pediatr Gastro Nutr 1984;3:535-8.
30. Williams GJ, Whitington PF, Weidman SW, Black DD, Sabesin SM. Correctable plasma lipoprotein abnormalities in infants with choledochal cyst. Pediatr Res 1985;19:240-7.
31. Whitington PF, Black DD, Struve W, Dockter ME. Evidence against an abnormal hepatic microsomal lipid matrix as the primary genetic defect in the jaundiced Gunn rat. Biochem Biophys Acta 1985;812:774-8.
32. Whitington PF. Portal hypertension in children. Pediatr Ann 1985;14:494-9.
33. Whitington PF. Cholestasis associated with total parenteral nutrition in infants. Hepatology 1985;5:693-6.
34. Orenstein SR, Whitington PF. Esophageal stricture dilatation in awake children. J Pediatr Gastro Nutr 1985;4:557-62.
35. Anuras S, Mitros FA, Soper RT, Pringle KC, Maves BV, Younoszai MK, Franken EA, Whitington PF. Chronic intestinal pseudoobstruction in young children. Gastroenterology 1986;91:62-70.
36. Helms RA, Whitington PF, Mauer EC, Catarau EM, Christensen ML, Borum PR. Enhanced lipid utilization in infants receiving oral L-carnitine during long term parenteral nutrition. J Pediatr 1986;109:984-8.
37. Whitington PF, Moscioni AD, Gartner LM. The effect of tin (IV)-protoporphyrin-IX on bilirubin excretion in the rat. Pediatr Res 1987;21:487-91.
38. Emond JC, Thistlethwaite JR, Baker AL, Whitington PF, Ferrari M, Carmellini M, Stuart FP, Broelsch CE. Rejection in liver allograft recipients: Clinical characterization and management. Clin Transplantation 1987;1:143-50.
39. Fox AS, Tolpin MD, Baker A, Broelsch C, Whitington PF, Jackson T, Thistlethwaite JR, Stuart F. Seropositivity in liver transplant recipients as a predictor of cytomegalovirus disease. J Infect Dis 1987;157:383-5.
40. Black DD, Haggitt RC, Whitington PF. Gastroduodenal endoscopic-histologic correlation in pediatric patients. J Pediatr Gastro Nutr 1988;7:353-8.
41. Broelsch CE, Emond JC, Thistlethwaite JR, Rouch DA, Whitington PF, Lichtor JL. Liver transplantation with reduced-sized donor organs. Transplantation 1988;45:519-24.
42. Whitington PF, Whitington GL. Eosinophilic gastroenteropathy in childhood. J Pediatr Gastro Nutr 1988;7:379-85.
43. Wasserman AL, Whitington PF, Rivara FP. Psychogenic basis for abdominal pain in children and adolescents. J Am Acad Child Adolesc Psychiatry 1988;27:179-84.
44. Rouch DA, Emond JC, Ferrari M, Yousefzadeh D, Whitington PF, Thistlethwaite JR, Broelsch CE. The successful management of portal vein thrombosis after hepatic transplantation with a splenorenal shunt. Surg Gynecol Obstet 1988;166:311-6.
45. Whitington PF, Whitington GL. Partial external diversion of bile for the treatment of intractable pruritus associated with intrahepatic cholestasis. Gastroenterology, 1988;95:130-6.
46. Bernstein EF, Whitington PF. Successful treatment of atypical sprue with cyclosporine. Gastroenterology 1988;95:199-204.
47. Hirsch BZ, Whitington PF, Kirschner BS, Black DD, Bostwick DG, Yousefzadeh DK. Isolated granulomatous gastritis in an adolescent. Dig Dis Sci 1988;34:292-6.
48. Kehrer BH, Whitington PF, Black DD. The effect of Roux-en-Y biliary-enterostomy on the absorption of cyclosporine: relevance to poor drug bioavailability in children after orthotopic liver transplantation. Transpl Proc 1988;20:523-7.
49. Tzakis MG, Arditi M, Whitington PF, Yanaga K, Esquivel C, Andrews WA, Makowka L, Malatak J, Freese DK, Stock PG, Ascher NL, Johnson FL, Broelsch CE, Starzl TE. Aplastic anemia complicating orthotopic liver transplantation for non-A, non-B hepatitis. N Engl J Med 1988;319:393-6.
50. Singer PA, Lantos JD, Whitington PF, Broelsch CE, Siegler M. Equipoise and the ethics of segmental liver transplantation. Clin Res 1988;36:539-45.
51. Broelsch CE, Emond JC, Thistlethwaite JR, Whitington PF, Zucker A, Baker AL, Aran PP, Rouch DA, Lichtor JL. Liver transplantation, including the concept of reduced-size liver transplants in children. Ann Surg 1988;208:410-20.
52. Emond JC, Aran PP, Whitington PF, Broelsch CE, Baker AL. Liver transplantation in the management of fulminant hepatic failure. Gastroenterology 1989;96:1583-8.
53. Whitington PF, Kehrer BH, Whitington SH, Shneider B, Black DD. The effect of biliary enteroenterostomy on the pharmacokinetics of enterally administered cyclosporine in rats. Hepatology 1989;9:393-7.
54. Broelsch CE, Vogelbach P, Emond JC, Thistlethwaite JR, Woodle SA, Baker AL, Whitington PF. Shunt surgery and its implication for liver transplantation. Langenbecks Arch Chir 1989:293-9.
55. Emond JC, Whitington PF, Thistlethwaite JR, Alonso EM, Broelsch CE. Reduced-size liver transplantation: use in the management of children with chronic liver disease. Hepatology 1989;10:867-72.
56. Singer PA, Siegler M, Whitington PF, Lantos J, Emond JC, Thistlethwaite JR, Broelsch CE. Ethics of liver transplantation using living donors. N Engl J Med 1989;321:620-2.
57. Ussery XT, Henar EL, Black DD, Berger S, Whitington PF. Acute liver injury after protracted seizures. J Pediatr Gastro Nutr 1989;9:421-5.
58. Hibbard JU, Pridjian G, Whitington PF, Moawad AH. Taurine transport in the in vitro perfused human placenta. Pediatr Res 1990;27:80-4.
59. Alonso EM, Fox AS, Franklin WA, Whitington PF. Post-necrotic cirrhosis following varicella hepatitis in a liver transplant patient. Transplantation 1990;49:650-2.
60. Singer PA, Siegler M, Lantos JD, Emond JC, Whitington PF, Thistlethwaite JR, Broelsch CE. The ethical assessment of innovative therapies: Liver transplantation using living donors. Theoretical Med 1990;11:87-94.
61. Woodle ES, Thistlethwaite JR, Emond JC, Whitington PF, Yousefzadeh DK, Broelsch CE. Successful hepatic liver transplantation in congenital absence of recipient portal vein. Surgery 1990;107:475-9.
62. Black DD, Haggitt RC, Orenstein SR, Whitington PF. Esophagitis in infants: morphometric histology and correlation with gastroesophageal reflux. Gastroenterology 1990;98:1408-14.
63. Whitington PF, Emond JC, Whitington SH, Broelsch CE, Baker AL. Small-bowel length and the dose of cyclosporine in children after liver transplantation. N Engl J Med 1990;322:733-8.
64. Broelsch CE, Emond JC, Whitington PF, Thistlethwaite JR, Baker AL, Lichtor JL. Application of reduced size liver transplants as split grafts, auxiliary orthotopic grafts and living related segmental transplants. Ann Surg 1990;212:368-77.
65. Emond JC, Whitington PF, Thistlethwaite JR, Cherqui D, Alonso EM, Woodle ES, Vogelbach P, Busse-Henry SM, Zucker AR, Broelsch CE. Transplantation of two patients with one liver: analysis of a preliminary experience with "split liver" grafting. Ann Surg 1990;212:14-22.
66. Cherqui D, Emond JC, Pietrabissa A, Mireille M, Roncella M, Brown SB, Whitington PF, Broelsch CE. Segmental liver transplantation from living donors: Report of the technical and preliminary results in dogs. HPB Surgery 1990;2:189-204.
67. Broelsch CE, Whitington PF, Emond JC. Evolution and future perspectives for reduced-size liver transplantation. Surg Gynecol Obstet 1990;171:353-60.
68. Thistlethwaite JR, Emond JC, Woodle ES, Vogelbach P, Black DD, Whitington PF, Broelsch CE. Increased utilization of organ donors: Transplantation of two recipients from single donor livers. Transpl Proc 1990;22:1485-6.
69. Woodle ES, Thistlethwaite JR, Emond JC, Whitington PF, Black DD, Aran PP, Baker AL, Stuart FP, Broelsch CE. OKT3 therapy for hepatic allograft rejection: Comparison of results in adults and children. Transpl Proc 1990;22:1765-6.
70. Harrison HH, Miller KL, Whitington PF. Improved detection, via ISO-DALT two dimensional electrophoresis, of "low Z expressor" individuals with alpha-1-antitrypsin MZ phenotype. Clin Chem 1990;36:1850.
71. Emond JC, Whitington PF, Broelsch CE. Overview of reduced-size liver transplantation. Clin Transpl 1991;5:168-73.
72. Whitington PF, Emond JC, Black DD, Whitington SH, Boone P, Smith C, Thistlethwaite JR, Broelsch CE. Indications for liver transplantation in pediatrics. Clin Transpl 1991;5:155-60.
73. Woodle ES, Thistlethwaite JR, Emond JC, Whitington PF, Black DD, Aran PP, Baker AL, Stuart FP, Broelsch CE. OKT3 therapy for hepatic allograft rejection. Differential response in adults and children. Transplantation 1991;51:1207-12.
74. Alonso EM, Zdunek T, Brown M, Yousefzadeh DK, Whitington PF. Fibroinflammatory tumor of the liver causing biliary cirrhosis in an infant. J Pediatr Gastro Nutr 1991;12:283-287.
75. Whitington PF, Balistreri WF. Pediatric liver transplantation: indications, contraindications, and pre-transplant management. J Pediatr 1991;118:169-177.
76. Alonso EM, Whitington PF, Whitington SH, Rivard WA, Given G. Enterohepatic circulation of non-conjugated bilirubin in rats fed human milk. J Pediatr 1991;118:425-30
77. Black DD, Rohwer-Nutter PL, Hay RV, Ellinas H, Stephens JK, Sherman H, Teng B-B, Davidson NO, Whitington PF. Studies of liver and intestine in a patient with abetalipoproteinemia undergoing liver transplantation. Gastroenterology 1991;101:520-8.
78. Tonsgard JH, Stephens J, Rhead WJ, Penn D, Horwitz AL, Kirschner BS, Whitington PF, Berger S, Tripp ME. Laboratory and pathologic findings in a patient with a defect in fatty acid metabolism. Pediatr Neurol 1991;7:125-30.
79. Broelsch CE, Stevens LH, Whitington PF. The use of reduced-size liver transplants in children, including split livers and living related liver transplants. Eur J Pediatr Surg 1991;1:166-71.
80. George DL, Arnow PM, Fox A, Baker AL, Thistlethwaite JR, Emond JC, Whitington PF, Broelsch CE. Bacterial infection as a complication of liver transplantation: Epidemiology and risk factors. Rev Inf Dis 1991;13:387-96.
81. Broelsch CE, Whitington PF, Emond JC, Heffron TG, Thistlethwaite JR, Stevens L, Piper J, Whitington SH, Lichtor JL. Liver transplantation in children from living related donors: Surgical techniques and results. Ann Surg 1991;214:428-39.
82. Thistlethwaite JR, Emond JC, Heffron TG, Whitington PF, Black DD, Broelsch CE. Innovative use of organs for liver transplantation. Transplant Proc 1991;23:2147-51.
83. Heffron TG, Emond JC, Whitington PF, Thistlethwaite JR, Stevens L, Piper J, Whitington S, Broelsch CE. Biliary complications in pediatric liver transplantation. Comparison of reduced size and whole grafts. Transplantation 1992;53:392-5.
84. Stevens LH, Emond JC, Piper JB, Heffron TG, Thistlethwaite JR, Whitington PF, Broelsch CE. Hepatic artery thrombosis in infants: A comparison of whole livers, reduced-size grafts and grafts from living donors. Transplantation 1992;53:396-9.
85. Rand ER, Whitington PF. Successful orthotopic liver transplantation in two patients with liver failure due to sclerosing cholangitis in the setting of Langerhans cell histiocytosis. J Pediatr Gastro Nutr 1992;15:202-07.
86. Rand ER, McClenathan DT, Whitington PF. Neonatal hemochromatosis -- report of successful orthotopic liver transplantation. J Pediatr Gastro Nutr 1992;15:325-9.
87. Bosma PJ, Chowdhury JR, Huang T-J, Lahari P, Oude Elferink RPJ, van Es HHG, Lederstein M, Whitington PF, Jansen PLM, Chowdhury NR. Mechanisms of inherited deficiencies of multiple UDP-glucuronyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I. FASEB J 1992;6:2859-63.
88. George DL, Arnow PM, Fox A, Thistlethwaite JR, Emond JC, Broelsch CE, Whitington PF. Patterns of infection after pediatric liver transplantation. Amer J Dis Child 1992;146:924-9.
89. Vedantham S, Taylor FC, Yousefzadeh DK, Udekwu P, Thistlethwaite JR, Whitington PF. Abdominal pain in a young girl due to congenital stenosis of the common bile duct with mucus plug formation. J Pediatr Gastro Nutr 1992;15:440-3.
90. Alonso EM, Gonzalez-Vallina R, Whitington PF. Update of pediatric liver transplantation. Europ J Pediatr 1992;151:S23-31.
91. Lloyd DM, Pieper F, Gundlach M, Knoefel WT, Burdelski M, Biermann CW, Emond JC, Heffron TG, Whitington PF, Broelsch CE. Developments in segmental and living related liver transplantation. Transpl Proc 1992;24:1287-92.
92. Contis JC, Heffron TG, Whitington PF, Emond JC. The use of an absorbable suture material in the vascular anastomoses in pediatric liver transplantation. Transplant Proc 1993;25:1878-80.
93. Ben-Ami TE, Martich V, Yousefzadeh DK, Whitington PF, Emond JC. Anatomical features of reduced-size liver transplant: Post-surgical imaging characteristics. Radiology 1993;187:165-70.
94. Rand EB, McCarthy CA, Whitington PF. Measles vaccination following orthotopic liver transplantation. J Pediatr 1993;123:87-9.
95. Ledley FD, Adams RM, Soriano HE, Darlington G, Finegold M, Lanford R, Carey D, Lewis D, Baley P, Rothenberg S, Kay M, Brandt M, Moen R, Anderson WF, Whitington PF, Pokorney W, Woo SLC. Development of a clinical protocol for hepatic gene transfer: lessons learned in pre-clinical studies. Pediatr Res 1993;33:313-22.
96. Emond JC, Heffron TG, Kortz EO, Gonzalez-Vallina R, Contis JC, Black DD, Whitington PF. Improved results of living related liver transplantation (LRT) with routine application in a pediatric program. Transplantation 1993;55:835-40.
97. Whitington PF, Emond JC, Heffron T, Thistlethwaite JR. Orthotopic auxiliary liver transplantation for Crigler-Najjar syndrome type I. Lancet 1993;342:779-80.
98. Gonzalez-Vallina R, Alonso EM, Rand E, Black DD, Whitington PF. Outpatient percutaneous liver biopsy in children. J Pediatr Gastro Nutr 1993;17:370-5.
99. Emond JC, Heffron TG, Whitington PF, Broelsch CE. Reconstruction of the hepatic vein in reduced size liver transplantation. Surg, Gyn, Obstet 1993;176:11-17.
100. Whitington PF, Freese DK, Alonso EM, Schwarzenberg SJ, Sharp HL. Clinical and biochemical findings in progressive familial intrahepatic cholestasis. J Pediatr Gastro Nutr 1994;18:134-41.
101. Alonso EM, Snover D, Whitington PF, Montag A, Freese DK. Histologic pathology of progressive familial intrahepatic cholestasis. J Pediatr Gastro Nutr 1994;18:128-33.
102. Aran PP, Bostwick DA, Bissell M, Ademac T, Whitington PF, Kane S, Baker AL. The clinical utility of liver biopsy in the diagnosis of post liver transplantation graft rejection. Clin Transpl 1994;7:475-81.
103. Shneider BL, Setchell KDR, Whitington PF, Neilson KA, Suchy FJ. D4-3-Oxosteroid-reductase deficiency presenting as neonatal liver failure and hemochromatosis. J Pediatr 1994;124:234-8.
104. Snyder ML, Hay RV, Whitington PF, Scanu AM, Fless GM. Binding and degradation of Lp(a) and LDL by primary human hepatocytes: Comparison to human monocyte-macrophages and fibroblasts. Arterioscler Thromb 1994 1994;14:770-9
105. Funaki B, Rosenblum JD, Leef JA, Hackworth CA, Szymski GX, Alonso EA, Piper JB, Whitington PF. Portal vein stenosis in children with segmental liver transplants: treatment with percutaneous transhepatic venoplasty. Am J Roentgenol 1995;165:161-5.
106. Loret de Mola O, Burnweit C, Whitington PF. Chronic pruritus and cholestasis. Internat Pediatr 1995;10:233-5.
107. Rand EB, Spinner NB, Piccoli DA, Whitington PF, Taub R. Molecular analysis of 24 Alagille syndrome families identifies a single submicroscopic deletion and further localizes the Alagille region within 20p12. Hum Genet 1995;57:1068-73.
108. Alonso EM, Sokol RJ, Hart J, Tyson W, Allswang M, Narkewicz MR, Whitington PF. Fulminant hepatitis associated with centrilobular hepatic necrosis in young children. J Pediatr 1995;127:888-94.
109. Emond JC, Whitington PF. Surgical management of progressive familial intrahepatic cholestasis. J Pediatr Surg 1995;30:1635-41.
110. Alonso EM, Piper JB, Echols G, Thistlethwaite JR, Whitington PF. Allograft rejection in pediatric recipients of living related liver transplants. Hepatology 1996;23:40-3.
111. Kostelic JK, Piper JB, Leef JA, Lu CT, Rosenblum JD, Hackworth C, Kahn J, Thistlethwaite JR, Whitington PF. Angiographic selection criteria for living related liver transplant donors. Am J Roentgenol 1996;166:1103-8.
112. Lee J, Ben-Ami T, Yousefzadeh D, Whitington PF, et al. Extrahepatic portal vein stenosis in recipients of living-donor allografts: Doppler sonography. Am J Roentgenol 1996;167:85-90.
113. Burress G, Ben-Ami T, Whitington PF. Pneumatosis intestinalis in infants after orthotopic liver transplantation. J Pediatr Gastro Nutr 1996:23:577-82.
114. Gokhale R, Whitington PF. Hepatic adenomatosis in an adolescent. J Pediatr Gastro Nutr 1996;23:482-6.
115. Newell KA, Alonso EM, Whitington PF, Bruce DS, Millis JM, Piper JB, Woodle ES, Kelly SM, Koeppen H, Hart J, Rubin CM, Thistlethwaite JR. Posttransplant lymphoproliferative disease in pediatric liver transplantation: interplay between primary Epstein-Barr virus infection and immunosuppression. Transplantation 1996;62:370-5
116. Seaman DS, Newell KA, Piper JB, Bruce DS, Woodle ES, Cronin DC, Alonso EM, Whitington PF, Thistlethwaite JR, Millis JM. Use of polytetrafluoroethylene patch for temporary wound closure after pediatric liver transplantation. Transplantation 1996;62:1034-6.
117. Millis JM, Seaman DS, Piper JB, Alonso EM, Kelly SM, Hackworth CA, Newell KA, Bruce DS, Woodle ES, Thistlethwaite JR, Whitington PF. Portal vein thrombosis and stenosis in pediatric liver transplantation. Transplantation 1996;62:748-54
118. Whitington PF, Rubin CM, Alonso EM, McKeithan TW, Anastasi J, Hart J, Thistlethwaite JR. Complete lymphoid chimersim and graft versus host disease in an infant recipient of a hepatic allograft from an HLA-homozygous parental living donor. Transplantation 1996;62:1516-9.
119. Newell KA, Rubin CM, Alonso EM, Hart J, Thistlethwaite JR, Whitington PF. The association between liver transplantation for Langerhans cell histiocytosis and the development of posttransplant lymphoproliferative disease in children. J Pediatr 1997;131:98-104
120. Newell KA, Millis JM, Bruce DS, Woodle ES, Cronin DC, Loss G, Grewal H, Alonso EM, Dillon JJ, Whitington PF, Thistlethwaite JR. An analysis of hepatic retransplantation in children. Transplant Proc 1997;29:442-3.
121. Sher LS, Cosenza CA, Michel J, Makowka L, Miller, CM, Schwartz ME, Busuttil R, McDiarmid S, Burdick JF, Klein AS, Esquivel C, Klintmalm G, Levy M, Roberts JP, Lake JR, Kalayoglu M, Gordon RD, Stieber AC, Shaw BW, Thistlethwaite JR, Whitington PF, Wiesner, R H, Porayko M, Cosimi AB, et al. Efficacy of tacrolimus as rescue therapy for chronic rejection in orthotopic liver transplantation: a report of the U.S. Multicenter Liver Study Group. Transplantation 1997;64:258-63.
122. Bartosh SM, Alonso EM, Whitington PF. Renal outcomes in pediatric liver transplantation. Clin Transplant 1997;11:354-60.
123. Cronin DC, Alonso EM, Piper JB, Newell KA, Bruce DS, Woodle ES, Whitington PF, Thistlethwaite JR, Millis JM. Biliary complications in living donor liver transplantation. Transplant Proc 1997;29:419-20.
124. Iyer L, King CD, Whitington PF, Green MD, Roy SK, Tephly TR, Coffman BL, Ratain MJ. Genetic predisposition to the metabolism of irinotecan (CPT11): role of UGT isoform 1A1 (UGT1A1) in the glucuronidation of its active metabolite (SN-38) in human liver microsomes. J Clin Invest 1998;101:847-54.
125. Allen KJ, Rand EB, Hart J, Whitington PF. Prognostic implications of centrilobular necrosis in pediatric hepatic allograft recipients. Transplantation 1998;65:692-8.
126. Hackworth CA, Leef JA, Rosenblum JD, Whitington PF, Millis J, Alonso EM. Transjugular intrahepatic portosystemic shunt creation in children: initial clinical experience. Radiology 1998;206:109-14.
127. Benya EC, Ben-Ami TE, Yousefzadeh DK, Millis JM, Alonso EM, Whitington PF. Position and appearance of the duodenum and duodenal-jejunal junction in children after liver transplantation. Radiology 1998;207:233-6.
128. Whitington PF, Alonso EM, Boyle JT, Molleston JP, Rosenthal P, Emond JC, Millis JM. Liver transplantation for the treatment of urea cycle disorders. J Inher Metab Dis 1998;21:112-8.
129. Newell KA, Millis JM, Bruce DS, Woodle ES, Cronin DC, Loss G, Grewal H, Alonso EM, Dillon JJ, Whitington PF. An analysis of hepatic retransplantation in children. Transplantation 1998;65:1172-8.
130. Woodle ES, Millis JM, So SKS, McDiarmid SV, Busuttil RW, Esquivel CO, Whitington PF, Thistlethwaite JR. Liver transplantation in the first three months of life. Transplantation 1998;66:606-9.
131. Rebhandl W, Felberbauer FX, Turnbull J, Paya K, Barcik U, Huber WD, Whitington PF, Horcher E. Biliary diversion by use of the appendix (cholecystoappendicostomy) in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 1999; 28:217-9.
132. El-Youssef M, Parsons WG, Whitington PF. Endoscopic retrograde cholangiopancreatography and endobiliary stenting for the treatment of a bile leak in a child. J Pediatr Gastroenterol Nutr 1999;29:350-3.
133. Bartosh SM, Thomas SE, Sutton MM, Brady LM, Whitington PF. Linear growth after pediatric liver transplantation. J Pediatr 1999;135:624-31
134. Bambini DA, Superina R, Almond PS, Whitington PF, Alonso EM. Experience with the Rex shunt (mesenterico-left portal vein bypass) in children with extrahepatic portal hypertension. J Pediatr Surg 2000;35:13-9.
135. Mack CL, Millis JM, Whitington PF, Alonso EM. Pulmonary complications following liver transplantation in pediatric patients. Pediatr Transpl 2000;4:39-44.
136. Hernandez HM, Kovarik P, Whitington PF, Alonso EM. Autoimmune hepatitis as a late complication of orthotopic liver transplantation. J Pediatr Gastroenterol Nutr 2001;32:131-6.
137. Rinella ME, Alonso E, Rao S, Whitington P, Fryer J, Abecassis M, Superina R, Flamm SL, Blei AT. Body mass index as a predictor of hepatic steatosis in living liver donors. Liv Transplant 2001;7:409-14.
138. Mack CL, Ferrario M, Abecassis M, Whitington PF, Superina RA, Alonso EM. Living donor liver transplantation for children with liver failure and concurrent multiple organ system failure. Liv Transplant 2001;7:890-5.
139. Allen KJ, Wassef SY, Tebbett IR, Whitington PF, Covert RF. Fetal gender and cocaine exposure as determinants of cord blood gamma-glutamyl transferase activity. J Perinatology 2002;22:133-6.
140. Emerick KM, Whitington PF. Partial external biliary diversion for intractable pruritus and xanthomas in Alagille syndrome. Hepatology 2002;35:1501-6.
141. Mack CL, Superina RA, Whitington PF. Surgical restoration of portal flow corrects the coagulation defects associated with extrahepatic portal vein thrombosis. J Pediatr 2003; 142:197-9.
142. Brown JB, Emerick KM, Brown DL, Whitington PF, Alsonso EM. Recombinant factor VIIa improves coagulopathy caused by liver failure. J Pediatr Gastroenterol Nutr 2003;37:268-72.
143. Carroll CL, Goodman DM, Superina RA, Whitington PF, Alonso EM. Timed Pediatric Risk of Mortality Scores predict outcomes in pediatric liver transplant recipients. Pediatr Transplant 2003;7:289-95.
144. Eroglu Y, Emerick KM, Whitington PF, Alonso EM. Octreotide therapy for control of gastrointestinal bleeding in children. J Pediatr Gastroenterol Nutr 2004;38:41-7.
145. Rabinowitz SS, Gelfond D, Chen C-K, Gloster ES, Whitington PF, Sacconi S, Salviati L, DiMauro S. Hepatocerebral mitochondrial depletion syndrome: Clinical and morphologic features of a nuclear gene mutation. J Pediatr Gastroenterol Nutr. 2004;38:216-20
146. Sahai A, Malladi P, Melin-Aldana H, Green RM, Whitington PF. Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a murine model. Am J Physiol Gastrointest Liver Physiol. 2004:287:G264-73.
147. Mack CL, Tucker RM, Sokol RJ, Kotzin BL, Whitington PF, Miller SD. Biliary atresia is associated with CD4+ Th1 cell-mediated portal tract inflammation. Pediatr Res 2004;56:79-87
148. Sahai A, Malladi P, Pan X, Paul R, Green RM, Whitington PF. Obese and diabetic db/db mice develop marked liver fibrosis in a model of nonalcoholic steatohepatitis: Role of short-form leptin receptors and osteopontin. Am J Physiol Gastrointest Liver Physiol. 2004;287:G1035-43.
149. Whitington PF, Hibbard JU. High dose immunoglobulin during pregnancy for recurrent neonatal haemochromatosis. Lancet 2004;364:1690-8.
150. Koppe SWP, Sahai A, Malladi P, Whitington PF, Green RM. Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient (MCD) diet. J Hepatology 2004;41:592-8.
151. Eroglu Y, Donaldson J, Sorensen LG, Vogelzang RL, Melin-Aldana H, Anderson JM, Whitington PF. Improved neurocognitive function after radiologic closure of congenital portosystemic shunts. J Pediatr Gastroenterol Nutr 2004;39:410-17.
152. Salvalaggio PR, Bambini DA, Donaldson J, Saker M, Whitington PF, Alonso EM, Superina RA. Simultaneous surgical and interventional radiological approach to treat complicated biliary strictures after pediatric liver transplantation. Pediatr Transplant. 2004;8:513-6.
153. Salvalaggio PRO, Whitington PF, Alonso EM, Superina RA. The presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantation. Liver Transpl 2004 (in press)
154. Superina R, Bambini DA, Lokar J, Rigsby C, Mack CL, Whitington PF. Mesenteric vein to left portal vein bypass provides physiologic correction of idiopathic extrahepatic portal vein thrombosis. (submitted)
155. Whitington PF, Malladi P, Melin-Aldana H, Azzam R, Mack CL, Sahai A. Expression of ostreopontin correlates with portal biliary proliferation and fibrosis in biliary atresia. Pediatr Res 2004 (in press)
156. Emerick KM, Krantz ID, Kamath BM, Darling C, Burrowes DM, Spinner NB, Whitington PF, Piccoli DA. Intracranial vascular abnormalities in Alagille patients. (submitted)
157. Mack CL, Zelko FA, Lokar J, Superina R, Alonso EM, Blei AT, Whitington PF. Minimal portal-systemic encephalopathy in children with primary extrahepatic portal vein thrombosis is corrected by surgically restoring portal flow to the liver. (submitted)
158. Salvalaggio P, Neighbors K, Kelly S, Emerick K, Iyer K, Superina RA, Whitington PF, Alonso EM. Regional variation and use of exception letters for cadaveric liver allocation in children with chronic liver disease. (submitted)
159. Kohli R, Harris DC, Whitington PF. Relative elevations of serum alanine and aspartate aminotransferase in muscular dystrophy. (submitted)
Abstracts (2002-04)
Whitington, PF. Immunomodulatory therapy during pregnancy prevents recurrent lethal neonatal hemochromatosis. Hepatology 2002; 36:336A.
Sahai, A, Green RM, Whitington PF. Upregulation of an inflammatory cytokine osteopontin precedes steatohepatitis in a mouse model of NASH. Hepatology 2002;36:405A
Igolnikov A, Spatz K, Whitington PF, Sahai A, Osmer E, Green RM. A polymorphism and increased expression of the hepatic enzyme PEMT correlate with the increased susceptibility of A/J mice to develop NASH on a methonine-choline deficient (MCD) diet. Hepatology 2002;36:402A
Bambini DA, Mack CL, Whitington PF, Alonso EM, Superina RA. The Rex shunt in children is the treatment of choice for symptomatic thrombosis of the extrahepatic portal vien. Hepatology 2002;36:219A.
Mack CL, Tucker RM, Kotzin BL, Sokol RJ, Whitington PF, Miller SD. Biliary atresia is associated with CD4+ TH1-cell mediated portal tract inflammation. J Pediatr Gastro Nutr 2003;37:399.
Besedovsky A, Neighbors K, Lokar J, Harric DC, Whitington PF, Emerick KM, Superina RA, Alonso EM. Single center comparison of outcomes in pediatric recipients of cadaveric and living donor liver transplantation. J Pediatr Gastro Nutr 2003;37:399
Sundaram SS, Stahulak B, Lokar JM, Whitington PF, Alonso, EM. Long term follow-up of de-novo autoimmune hepatitis in pediatric liver transplant recipients Hepatology 2003; 38:371A.
Pawlikowska L, et al (including Whitington PF). Surgical intervention outcomes in FIC1 (ATP8B1) and BSEP (ABCB11) disease. Hepatology 2003; 38:483A
Sahai A, Malladi P, Green RM, Whitington PF. Steatohepatitis and liver fibrosis associated with upregulated osteopontin expression in diabetic/insulin resistant DB/DB mice fed a methionine and choline deficient diet. Hepatology 2003; 38:497A
Whitington PF, Malladi P, Melin-Aldana H, Mack CM, Sahai A. Upregulation of a TH1 cytokine osteopontin in patients with biliary atresia: differential localization at diagnosis and at transplant. Hepatology 2003; 38:525A
Salvalaggio P, Iyer K, Whitington PF, Alonso EM, Superina R. The presence of multiple bile ducts in the liver graft increases the incidence of biliary complications in pediatric liver transplantation. Amer J Transplant 2004;4(suppl 8):382.
Salvalaggio P, Neighbors K, Kelly S, Emerick K, Iyer K, Superina R, Whitington PF, Alonso EM. Has the PELD system improved organ allocation for pediatric liver transplant recipients with chronic liver disease? Amer J Transplant 2004;4(suppl 8):437.
Shneider B, Brown M, Sokol R, Whitington P, Schwarz K, Squires R, Bucuvalas J, Haber B, Shepherd R, Rosenthal P, Robuck P; BARC. A mulit-center analysis of outcome at 24 months of age in children with biliary atresia in the United States. Hepatology 2004;40(suppl 1): 201A
Mack CL, Zelko FA, Alonso EM, Lokar J, Superina R, Whitington PF. Sub-clinical portal-systemic encephalopathy (PSE) in children with primary extrahepatic portal vein thrombosis (EHPVT) is corrected by surgically restoring portal flow to the liver. Hepatology 2004;40(suppl 1): 200A
Sahai A, Pan X, Paul R, Malladi P, Whitington P